|The Aging Research Axis is the largest program of its type in Canada, distinguished by its multi-disciplinary study of the basic biology of aging and age-related disease. Primary themes include:• Cognitive Neurosciences and Alzheimer’s Disease• Molecular and Cellular Biology of Aging• Biological and Clinical Studies of Aging BonesIt has an active clinical component addressing cognitive impairment, neuro-imaging of stroke and dementia, and health services delivery for the elderly. Many of these activities are brought together in the the Bloomfield Centre for Research in Aging. Members of the axis hold primary academic appointments within the Departments of Neurology and Neurosurgery, Medicine, Surgery, and Anatomy and Cell Biology at McGill. Drs. Howard Chertkow and Hyman Schipper are pursuing ground-breaking work to identify the predictors and causes of dementia, conditions which will reach crisis proportions as our population continues to age. By exploring the molecular and cellular biology of aging, Drs. Chantal Autexier, Andréa Leblanc, and Hemant Paudel and are seeking to identify those mechanisms controlling the survival and demise of cells, which could hold the key to a number of age-related conditions. Dr. Alexander Thiel is employing the most advanced imaging techniques to gain new insights into how to maximize recovery following a stroke. Dr. Andrew Karaplis' work on how circadian rhythms influence osteoporosis points to new directions for therapy for this disorder. Dr. John Antoniou conducts basic and clinical reseach on quantitative MRI as a diagnostic tool of disc degeneration, tissue engineering of the intervertebral disc, and total hip arthroplasty. As people live longer, understanding the aging process has become more critical to sustaining quality of life. LDI Aging Axis researchers are contributing to advances against some of the more debilitating conditions of advanced age.
Cognitive Neurosciences and Alzheimer's Disease
Molecular and Cellular Biology of Aging
Biological and Clinical Studies of Aging Bone