Senior Investigator, Lady Davis Institute, Jewish General Hospital
Professor of Anatomy and Cell Biology, and of Medicine, McGill University
Chercheur national of the Fonds de recherche Québec - Santé
Dr. Autexier obtained her Ph.D. from the Microbiology and Immunology Department at McGill University in 1991 and pursued postdoctoral training with Carol W. Greider at Cold Spring Harbor Laboratory in New York from 1991 to 1996. She is best known for her studies identifying and characterizing essential determinants of telomerase function (Autexier, C. and Lue, N.F. 2006. The structure and function of telomerase reverse transcriptase. Annual Review of Biochemistry, 75, 493-517). Her current research team is actively pursuing the identification and characterization of mechanisms that regulate telomerase and telomere function, and cell survival, with the long term objective to develop anti-cancer therapies that target telomerase or telomeres. She is co-organizer of the Canadian Symposiums on Telomeres and Genome Integrity.
Major Research Activities
The long-term objective of Dr. Autexier’s research is the development of anti-cancer therapies that target telomerase or telomere function.
Her research team’s short-term objectives are to: 1) identify and characterize the mechanisms that regulate telomerase and telomere function; and 2) evaluate the principles of anti-cancer strategies that target telomerase or telomere function.
Chu, T.W., D’Souza, Y. and Autexier, C. 2015. The insertion in fingers domain in human telomerase can mediate enzyme processivity and telomerase recruitment to telomeres in a TPP1-dependent manner. Molecular and Cellular Biology. 2015 Oct 26. pii: MCB.00746-15. [Epub ahead of print]
D’Souza, Y., Lauzon, C., Chu, T.W., and
Autexier, C. 2013. Regulation of human telomere length and homeostasis
by telomerase enzyme processivity. J. Cell Science. 126, 676-87. Nov 23.
[Epub ahead of print].
D’Souza, Y., Chu, T.W., Autexier, C. 2013. A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization. Mol. Biol. Cell. 24, 1469-79. Epub 2013 Feb 27.Brault, M.E., Lauzon, C. and Autexier, C. 2013. Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects. Hum. Mol. Genet. 22, 3498-507. Epub 2013
Brault, M.E. and Autexier, C. 2011. Telomeric recombination is induced by dysfunctional telomeres. Mol. Biol. Cell. 22, 179-188. Epub 2010 Nov 30.