Senior Investigator, Lady Davis Institute, Jewish General Hospital
Professor of Anatomy and Cell Biology, and of Medicine, McGill University
Chercheur national of the Fonds de recherche Québec - Santé
Dr. Autexier obtained her Ph.D. from the Microbiology and Immunology Department at McGill University in 1991 and pursued postdoctoral training with Carol W. Greider at Cold Spring Harbor Laboratory in New York from 1991 to 1996. She is best known for her studies identifying and characterizing essential determinants of telomerase function (Autexier, C. and Lue, N.F. 2006. The structure and function of telomerase reverse transcriptase. Annual Review of Biochemistry, 75, 493-517). Her current research team is actively pursuing the identification and characterization of mechanisms that regulate telomerase and telomere function, and cell survival, with the long term objective to develop anti-cancer therapies that target telomerase or telomeres. She is co-organizer of the Canadian Symposiums on Telomeres and Genome Integrity.
Major Research Activities
The long-term objective of Dr. Autexier’s research is the development of anti-cancer therapies that target telomerase or telomere function.
Her research team’s short-term objectives are to: 1) identify and characterize the mechanisms that regulate telomerase and telomere function; and 2) evaluate the principles of anti-cancer strategies that target telomerase or telomere function.
Dan, J., Rousseau, P., Hardikar, S., Veland, N., Wong, J., Autexier, C. and Chen, T. 2017. Zscan4 inhibits maintenance DNA methylation to regulate telomere elongation in mouse embryonic stem cells. Cell Reports, 20(8):1936-1949.
Chu, T.W., MacNeil, D. and Autexier, C. 2016. Multiple mechanisms contribute to the cell growth defects imparted by human telomerase insertion in finger domain mutations associated with premature aging diseases. Journal of Biological Chemistry, 291, 8374-8386.
Chu, T.W., D’Souza, Y. and Autexier, C. 2016. The Insertion in Fingers Domain in human telomerase can mediate enzyme processivity and telomerase recruitment to telomeres in a TPP1-dependent manner. Molecular and Cellular Biology. 1, 210-222.
Brault, M.E., Lauzon, C. and Autexier, C. 2013. Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects. Hum. Mol. Genet. 22, 3498-507.
D’Souza, Y., Lauzon, C., Chu, T.W., and Autexier, C. 2013. Regulation of human telomere length and homeostasis by telomerase enzyme processivity. J. Cell Science. 126, 676-87.