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Dr. Chantal Autexier
Associate Director for Faculty Development and Training, Lady Davis Institute for Medical Research, Jewish General Hospital
Professor of Anatomy, Cell Biology, and Medicine, McGill University

Dr. Autexier obtained her Ph.D. from the Microbiology and Immunology Department at McGill University in 1991 and pursued postdoctoral training with Carol W. Greider at Cold Spring Harbor Laboratory in New York from 1991 to 1996. She is best known for her studies identifying and characterizing essential determinants of telomerase function (Autexier, C. and Lue, N.F. 2006. The structure and function of telomerase reverse transcriptase. Annual Review of Biochemistry, 75, 493-517). Her current research team is actively pursuing the identification and characterization of mechanisms that regulate telomerase and telomere function, and cell survival, with the long term objective to develop anti-cancer therapies that target telomerase or telomeres. She is chercheur national of the Fonds de la recherche en santé du Québec and co-organizer of the Canadian Symposiums on Telomeres and Telomerase.

Major Research Activities

The long-term objective of Dr. Autexier’s research is the development of anti-cancer therapies that target telomerase or telomere function.

Recent Publications

Moriarty, T.J., Ward, R.J. Taboski, M.A.S. Autexier, C. 2005. An Anchor Site-type Defect in Human Telomerase that Disrupts Telomere Length Maintenance and Cellular Immortalization. Mol. Biol Cell. 16, 3152-3161.


Marie-Egyptienne, D.T., Brault, M.E., Zhu, S. and Autexier, C. 2008. Telomerase inhibition in a mouse cell line with long telomeres leads to rapid telomerase reactivation. Exp. Cell Res. 314, 668-675.

Fakhoury, J., Marie-Egyptienne, D.T., Londoño-Vallejo J.A. and Autexier, C. 2010. Telomeric function of mammalian telomerases at short telomeres. J. Cell Science. In press.
The research team led by Dr. Autexier has two short-term objectives:

1) Identify and characterize the mechanisms that regulate telomerase and telomere function;

2) Evaluate the principles of anti-cancer strategies that target telomerase or telomere function.
 

Dr. Autexier's Publications Indexed on PubMed

Profile at McGill University

Profile at McGill Faculty of Medicine

Profile at Bloomfield Centre for Research in Aging


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