Associate Director for Faculty Development and Training, Lady Davis Institute for Medical Research, Jewish General Hospital
Professor of Anatomy, Cell Biology, and Medicine, McGill University
Dr. Autexier obtained her Ph.D. from the Microbiology and Immunology Department at McGill University in 1991 and pursued postdoctoral training with Carol W. Greider at Cold Spring Harbor Laboratory in New York from 1991 to 1996. She is best known for her studies identifying and characterizing essential determinants of telomerase function (Autexier, C. and Lue, N.F. 2006. The structure and function of telomerase reverse transcriptase. Annual Review of Biochemistry, 75, 493-517). Her current research team is actively pursuing the identification and characterization of mechanisms that regulate telomerase and telomere function, and cell survival, with the long term objective to develop anti-cancer therapies that target telomerase or telomeres. She is chercheur national of the Fonds de la recherche en santé du Québec and co-organizer of the Canadian Symposiums on Telomeres and Telomerase.
Major Research Activities The long-term objective of Dr. Autexier’s research is the development of anti-cancer therapies that target telomerase or telomere function.
Moriarty, T.J., Ward, R.J. Taboski, M.A.S. Autexier, C. 2005. An Anchor Site-type Defect in Human Telomerase that Disrupts Telomere Length Maintenance and Cellular Immortalization. Mol. Biol Cell. 16, 3152-3161.
Fakhoury, J., Marie-Egyptienne, D.T., Londoño-Vallejo J.A. and Autexier, C. 2010. Telomeric function of mammalian telomerases at short telomeres. J. Cell Science. In press.
Marie-Egyptienne, D.T., Brault, M.E., Zhu, S. and Autexier, C. 2008. Telomerase inhibition in a mouse cell line with long telomeres leads to rapid telomerase reactivation. Exp. Cell Res. 314, 668-675.