Senior Investigator, Lady Davis Institute
Director, Segal Cancer Proteomics Centre,
Professor, Department Oncology, Faculty of Medicine, McGill University
Dr. Christoph Borchers became a Professor in the Gerald Bronfman Department of Oncology in 2015 and currently holds the Segal Chair in Molecular Oncology. He received his PhD from the University of Konstanz, Germany (1996). After post-doctoral and staff scientist positions at the National Institute of Environmental Health Sciences (NIEHS)-NIH (NC, USA), he became the director of the University of North Carolina-Duke Proteomics Facility, and held a faculty position at the UNC Medical School (2001-2006). Since 2006, Dr. Borchers has been a professor at the University of Victoria (UVic), BC, Canada, where he currently holds a professorship in the Department of Biochemistry and Microbiology, the Rix BC Leadership Chair in Biomedical and Environmental Proteomics, and directorship of the UVic-Genome BC Proteomics Centre. Dr. Borchers is also appointed Honorary Professor of Fudan University, China 2017 – 2022.
Major Research Activities
Dr. Borchers' research involves the improvement, development, and application of proteomics and metabolomics technologies, especially quantitative techniques for clinical diagnostics; his research also involves the application of protein chemistry and mass spectrometry (MS) to problems in structural proteomics, with particular emphasis on the mechanism of aggregation of disease-related proteins involved in neurodegenerative diseases.
LeBlanc A, Michaud SA, Percy AJ, Hardie DB, Yang J, Sinclair NJ, Proudfoot JI, Pistawka A, Smith DS, Borchers CH. Multiplexed MRM-based Protein Quantitation Using Two Different Stable Isotope Labeled Peptides for Calibration. J Proteome Res, 16(7): 2527-2536 (2017).
Han J, Higgins R, Lim MD, Lin K, Yang J, Borchers CH. Short-Term Stabilities of 21 Amino Acids in Dried Blood Spot. Clin Chem, 2017 Nov 2. pii: clinchem.2017.278457. doi: 10.1373/clinchem.2017.278457. [Epub ahead of print].
Popp R, Li H, LeBlanc A, Mohammed Y, Aguilar-Mahecha A, Chambers AG, Lan C, Poetz O, Basik M, Batist G, Borchers CH. Immuno-MALDI (iMALDI) for quantifying AKT1 and AKT2 in breast and colorectal cancer cell lines and tumors. Anal Chem, 2017 Aug 30. doi: 10.1021/acs.analchem.7b02934. [Epub ahead of print].
Brodie NI, Popov KI, Petrotchenko EV, Dokholyan NV, Borchers CH.Solving protein structures using short-distance cross-linking constraints as a guide for discrete molecular dynamics simulations. Science Advances, 3(7): e1700479 (2017).