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Dr. Volker Blank
Project Director, Lady Davis Institute
Associate Professor, Department of Medicine, McGill University


Dr. Volker Blank received his doctorate from the University of Paris VI (Pierre & Marie Curie) and the Pasteur Institute in Paris. He did his postdoctoral training at Stanford University in Palo Alto, California and Harvard Medical School in Boston. Dr. Blank is currently an Associate Professor in the Department of Medicine at McGill University and a Project Director at the Lady Davis Institute, Jewish General Hospital. He is also an Associate Member of the Department of Physiology at McGill University.

Major Research Activities

Dr. Blank’s laboratory is interested in the functions of the CNC and small Maf basic-leucine zipper transcription factors. The research team he leads has the following objectives: 1) Analyze the molecular mechanisms that regulate the differentiation of erythroid cells, with particular emphasis on the p45 NF-E2 transcription factor; 2) Determine the role of the Nrf3 transcription factor in mammalian gene regulation; 3) Examine the regulation of the MafF protein in proinflammatory cytokine signaling. The long-term goal of these studies is to design novel treatment options for patients with erythroid cell disorders and cancer.

Recent Publications

Gasiorek J, Nouhi Z, Derjuga A & Blank V. Abnormal differentiation of erythroid precursors in p45 NFE2-/- mice. Experimental Hematology 2012, 40:393-400.

Chevillard G, Paquet M & Blank V. Nfe2l3 (Nrf3) deficiency predisposes mice to T-cell lymphoblastic lymphoma. Blood 2011, 117; 2005-2008.

Mardini L, Gasiorek J, Derjuga A, Carrière L, Paw BH, Schranzhofer M, Ponka P & Blank V. Antagonistic Roles of ERK and p38 MAP kinases in globin expression, heme biosynthesis and iron uptake in erythroid cells. Biochem J 2010, 432: 145-151. 
 
Dr. Blank is an internationally recognized researcher in the fields of erythropoiesis and cancer.

He participated in the first cloning and analysis of NF-kappaB, a transcriptional regulator that plays a key role in immunity and infection.

He is known for his studies on CNC and Maf transcription factor family members that play important roles in mammalian differentiation, oncogenesis and stress response.
 

Dr. Blank's Publications Indexed on PubMed

Dr. Blank’s website at the McGill University Division of Experimental Medicine

Dr. Blank’s website at the McGill University Department of Physiology


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