Tel.: 514-340-8222 ext. 25588
Hyman M. Schipper, MD, PhD, FRCPC
Senior Investigator, Lady Davis Institute
Professor, Neurology and Medicine, McGill University
Dr. Schipper received his M.D. and Ph.D. (Neuroendocrinology) degrees at McGill University in 1982. He studied Internal Medicine at McGill University, Neurology at Columbia University, and Endocrinology at Tufts University. Dr. Schipper is currently tenured Professor of Neurology and Medicine (Geriatrics) at McGill, staff neurologist at the Jewish General Hospital, and consultant at other Montreal institutions. He is founding director of the Centre for Neurotranslational Research, a Biomedical Redox Laboratory and the Alzheimer Risk Assessment Clinic at the Jewish General Hospital, and a founding scientist of Molecular Biometrics Inc.

Major Research Activities

Dr. Schipper’s long-standing research interests are in the fields of oxidative stress, brain aging and neurodegenerative diseases. Three papers (1980-3) emanating from his doctoral thesis provided the earliest published evidence that chronic exposure to ovarian estrogen promotes aging-related degenerative changes in rodent brain regions implicated in reproductive senescence and the development of polycystic ovaries. Since 1990, his laboratory has contributed a large body of evidence and novel theory concerning the role of heme oxygenase-1 (HO-1) and iron-containing astroglia in CNS senescence and free radical-related neurodegenerative disorders. A major research focus of his laboratory is the development of blood-based biological markers for the early diagnosis and prognosis of sporadic Alzheimer disease and other degenerative human CNS afflictions. Dr. Schipper’s laboratory has received generous support from the Canadian Institutes for Health Research, the Fonds de la recherche en santé du Québec and several other Canadian and American funding agencies. Dr. Schipper has published over 170 articles on various aspects of the redox neurosciences and related topics in peer-reviewed journals and is an inventor on twelve patents. In 1998, he edited the first book of its genre, entitled Astrocytes in Brain Aging and Neurodegeneration (RG Landes Co.). He co-edited a volume for the Annals of the New York Academy of Sciences on brain metals in 2004, and recently co-edited a 3-volume text entitled Principles of Free Radical Biomedicine (2012). He served on the Editorial Board of the Journal of Neurochemistry and is a member of numerous professional societies. He has given over 130 invited lectures, seminars, and presentations in Canada, the United States, Europe, and Israel. At McGill University and the Jewish General Hospital, Dr. Schipper provides basic and clinical teaching in the neurosciences and coordinates an interdisciplinary course on Free Radical Biomedicine in the Faculty of Science.
The videoclips demonstrate robust spontaneous circling behavior (stereotypy)
in a forty-eight week old GFAP.HMOX1 transgenic mouse which is not observed
in an age-matched wild-type (WT) control animal. The videos were recorded
at the Neurophenotyping Centre of the Douglas Mental Health University Institute (McGill University, Montreal).
Song W, Zukor H, Lin S-H, Hascalovici J, Liberman A, Tavitian A, Mui J, Vali H, Tong X-K, Bhardwaj SK, Srivastava LK, Hamel E, Schipper HM. Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment. J Neurosci, in press (2012).
Recent Publications
Gupta A, Lacoste B, Paul J. Pistel PJ, Ingram DK, Hamel E, Alaoui-Jamali MA, Szarek WAVlahakis JZ, Jie S, Song W, Schipper HM. Neurotherapeutic effects of novel HO-1 inhibitors in vitro and in a transgenic mouse model of Alzheimer’s disease. J Neurochem131: 778–790, 2014.

Chen-Roetling J., SongW, Schipper HM, Christopher S. Regan CS, Regan RF. Astrocyte overexpression of heme oxygenase-1 improves outcome after intracerebral hemorrhage. Stroke 46:00-00, 2015; DOI: 10.1161/STROKEAHA.115.008686.

Ravina B, Eberly S, Oakes D, Lang AE, Dodelet V, Roos P, Harman J, Shoulson I, Schipper HM. Plasma near-infrared spectroscopy for diagnosis of idiopathic Parkinson disease – the SPIN-PD study. Biomarkers Med 9:89-97, 2015. [Also listed in NIR NEWS 26 (6): 19, 2015].

Lin S-H, Song W, Cressatti M, Zukor H, Wang E, Schipper HM. Heme oxygenase-1modulates microRNA expression in cultured astroglia: Implications for chronic brain disorders. GLIA 63:1270–1284, 2015.
In progress.
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