The Lady Davis Institute for Medical Research (LDI) offers outstanding training opportunities for postdoctoral fellows, clinical research fellows, graduate and undergraduate students in partnership with McGill University. Join us at the LDI! Below is the list of trainee opportunities currently available at the LDI. This list is updated regularly, so please check back often.
The LDI is committed to equity, diversity and inclusion within its community. The LDI has an equal opportunity employment program and welcomes applications from all qualified candidates, regardless of their characteristics, with the skills and knowledge to productively engage with diverse communities. Accommodation for any part of the application process may be provided to persons with disabilities who request it.
Department:
Lady Davis Institute for Medical Research (LDI) – Cancer Axis
Supervisor:
Dr. Melica Brodeur, MSc, MD, Assistant Professor, departments of Obstetrics and Gynecology and of Oncology, McGill University
Project description:
We are seeking a highly motivated, independent Postdoctoral Fellow with strong expertise in molecular biology and animal experimentation to lead a cutting-edge translational research project. Ovarian cancer (OC) remains the most lethal gynecologic malignancy, primarily due to the development of chemoresistant disease and a highly immunosuppressive tumor microenvironment (TME) that limits the efficacy of current immune checkpoint blockade (ICB) therapies.
Funded on the basis of innovative preliminary data, this project aims to evaluate a novel combinatorial therapeutic strategy. By combining targeted epi-therapies (inhibitors of the catalytic subunits of the SWI/SNF chromatin remodeling complex, BRG1/BRM, and the DNA methyltransferase), we seek to restore the intrinsic immunogenicity of tumor cells and sensitize epithelial OC to ICB (anti-PD1). The postdoctoral fellow will play a leading role in characterizing inflammatory signaling pathways and conducting pre-clinical in vivo validation of these synergistic combinations.
The Postdoctoral Fellow will be fully integrated into a dynamic, multidisciplinary team comprising clinician-scientists, pathologists, oncologists, and clinical biologists. The laboratory provides direct access to state-of-the-art technological infrastructure (genomics platforms, mass/flow cytometry cores, and small animal imaging at the LDI) along with annotated clinical biorepositories, offering an exceptional training environment for a career in precision oncology.
The ideal candidate holds a recently obtained PhD (or nearing defense) in Molecular Biology, Immuno-Oncology, Genetics, Biomedical Sciences, or a closely related discipline and has substantial hands-on experience in molecular biology (RT-qPCR, Western blot, knockout/knockdown experimentation) as well as proficiency in multicolor flow cytometry and data analysis (FlowJo). The Postdoctoral Fellow should also have competency in handling rodent models; autonomy or familiarity with high-throughput sequencing data analysis pipelines (RNA-seq) and standard statistical software; and a strong track record of first-author publications in well-regarded, peer-reviewed journals.
Interested applicants must submit their application package as a single PDF file containing:
Applications should be sent via email to: melica.brodeur@mcgill.ca.
Department:
BC Children’s Hospital Research Institute
Supervisors:
Dr. Wazana is a Child Psychiatrist, Associate Professor, Department of Psychiatry and Director, Early Childhood Disorders psychiatric day hospital, Jewish General Hospital, studying pre- and perinatal influences on lifetime psychopathology.
Dr. Oberlander is a Developmental Pediatrician, Professor, Dept of Pediatrics and School of Population and Public Health, studying how early experiences influence child development.
Dr. Laplante is a research scientist with expertise in perinatal impacts (disasters, maternal mood, socio-environmental) on development across the lifespan.
Project description:
A collaboration between the Lady Davis Institute for Medical Research (LDI: Montreal, Quebec) and the BC Children’s Hospital Research Institute (BCCHR: Vancouver, British Columbia) is now accepting applications for the 2022 Webster Postdoctoral Scholars Program to support exceptional research trainees and generate innovative research in Child Development and Neuroscience under the mentorship of Drs. Ashley Wazana (McGill University) and Tim Oberlander (university of British Columbia) in the area of developmental neuroscience. The postdoctoral scholar will also work closely with Drs. David P Laplante and François Freddy Ateba (LDI) in onboarding the rich UBC longitudinal dataset, Pregnancy during the COVID-19 Pandemic study, into the Developmental Research in Early Adversity Mental Health BIological Susceptibility and Gender (DREAM BIG) consortium of perinatal longitudinal birth cohorts, focusing on the harmonization and analysis of the UBC perinatal maternal adversity and child mental health outcomes from the so that comparable analyses can be performed across the DREAM BIG cohorts in an effort to increase replication of mental health findings that can inform treatment and public policy.
The goal of the program is to support recent a PhD or MD graduate in conducting clinical and translational research with the intent to develop future leaders in Child Developmental Health research.
Applicants should have training in neuroscience, psychology, medical sciences (Pediatrics), or other relevant discipline, and experience with MR image acquisition, processing, and/or analysis.
Interested candidates should submit a letter of interest, CV, graduate transcript(s), and names and contact information for at least two references to Dr. Tim Oberlander (email: toberlander@bcchr.ca).
Department:
Lady Davis Institute for Medical Research, Jewish General Hospital.
Supervisor:
Mark Trifiro, MD, professor in the Division of Experimental Medicine at McGill University and senior researcher at the Lady Davis Institute for Medical Research of the Jewish General Hospital.
Project description:
MITACS funds are available for the recruitment for a post-doctoral fellow, that will oversee large scale efficacy of targeted multi-walled carbon nanotubes for the photothermal ablation of xenograft prostate cancer tumors.
As part of our route towards development of the technology for clinical applicability as a photothermal treatment for prostate cancer (PCa), we will be determining the efficacy of our Glu-urea-Lys-MWCNT nanoformulation platform by assessing tumor recurrence and disease-free outcomes The Glu-urea-Lys-MWCNT formulation uses a peptidomimetic compound that binds to the Prostate Specific Membrane Antigen (PSMA); a PCa-specific surface receptor whose expression is correlated with disease onset and progression.
Simultaneously, tests will also be performed to assess photothermal therapy safety of the nanoformulation, biochemical blood testing, histopathological analysis and. adverse events will be documented.
Interested candidates are invited to submit a CV and cover letter by email to Dr. Mark Trifiro at: mark.trifiro@mcgill.ca and Dr. Miltiadis Paliouras at mpaliouras@guzzonanoresearch.ca.
Note: This position is supported by MITACS award.
Department:
Department of Psychiatry, Jewish General Hospital and McGill University.
Supervisors:
Danielle Groleau, PhD, full professor in the Division of Social and Transcultural Psychiatry at McGill University and senior researcher at the Lady Davis Institute for Medical Research of the Jewish General Hospital
Project description:
The postnatal period represents a challenge for many mothers, making them vulnerable to psychiatric disorders, particularly depressive episodes. Maternal PND can have adverse effects on both mother and infant, often leading to early weaning. Conversely, successful breastfeeding has been associated with an improvement in PND symptoms. Despite this, the underlying mechanisms of the relationship between PND and breastfeeding remain poorly understood. This study aims to fill this gap by focusing on cultural communities such as Orthodox and Hasidic Jewish as well as South Saharan African women, where breastfeeding despite DPN is much more prevalent.
Interested candidates should submit a cover letter, curriculum vitae, a brief (1-page) statement of research interests and career goals, and contact information for five references. Please send your application to psychosocial.ccomtl@ssss.gouv.qc.ca with the subject line “Application Postdoctoral Fellow – [Your Name]”. Applications will be considered until the position is filled.
Note: This postdoctoral fellowship is conditional on obtaining a UTTING fellowship from the Department of Psychiatry at the Jewish General Hospital.
