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We study how oncogenic forms of stress influence tumor development and their responses to chemotherapy. Our research focuses on the integrated stress response (ISR), a key pathway that determines the efficacy of adaptation processes through the regulation of protein synthesis. We examine the anti-tumor efficacy of drugs targeting protein synthesis pathways and how tumor cells adapt to these treatments. Additionally, we investigate the function of the transcription factor STAT1 in solid cancers to understand its pro-survival mechanisms and their impact on cancer therapies.
The long-term goals of our research are to:
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