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Dr. Mark J. Eisenberg’s research focuses on the primary and secondary prevention of cardiovascular disease, with topics ranging from interventional cardiology to broad public health issues such as smoking and obesity. His latest randomized controlled trial (RCT), the Aggressive Smoking Cessation Therapy Among People at Elevated Cardiovascular Risk (ASAP) Trial, is a multi-centre clinical trial that assesses the efficacy, safety, and tolerability of aggressive smoking cessation therapy among people at elevated cardiovascular risk. A total of 798 participants are being randomized 1:1 to: (1) varenicline and nicotine e-cigarettes (aggressive smoking cessation therapy), or (2) varenicline alone for 12 weeks, with follow-up of 52 weeks. The ASAP Trial design builds off of his most recently completed RCT, E3 (see citations under ‘Recent Publications’), the results of which suggest that nicotine e-cigarettes are moderately efficacious for smoking cessation.
Dr. Mark J. Eisenberg is a James McGill Professor of Medicine at McGill University and a Staff Cardiologist at the Jewish General Hospital. He is an Associate Member of the McGill Department of Epidemiology, Biostatistics, and Occupational Health. In addition to his clinical responsibilities, Dr. Eisenberg is Director of the Cardiovascular Health Services Research Group of the Jewish General Hospital and a Senior Investigator at the Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research.
Dr. Eisenberg was born in Rochester, New York. He completed a BA in Chemistry in 1980 at Cornell University, followed by an MD at the University of Rochester. After completing his MD, Dr. Eisenberg did a residency in internal medicine at McGill University, a Masters of Public Health at Harvard University, a research fellowship in echocardiography and epidemiology and a cardiology fellowship at the University of California in San Francisco. In 1995, Dr. Eisenberg completed an interventional cardiology fellowship at the Cleveland Clinic.
In 2008-2009, Dr. Eisenberg spent a year in Israel as a visiting professor in the Department of Human Metabolism and Nutrition at the Joseph H. and Belle R. Braun Hebrew University, Hadassah School of Public Health and Community Medicine. During this sabbatical, he also completed an International Master’s of Health Leadership at McGill University.
Dr. Eisenberg is married and has five children. He is fluent in English, French, and Hebrew.
Over the course of his career, Dr. Mark J. Eisenberg has published over 300 articles in peer-reviewed journals and participated in multiple collaborative works.
His research team is examining the use and effectiveness of various smoking cessation pharmacotherapies with several randomized controlled trials.
In addition, Dr. Eisenberg has authored four books, the links for which are listed under the “Important Links” section of this page.
Filion KB, Zolotarova T, Hébert-Losier A, Windle SB, Reynier P, Greenspoon T, Brandys T, Fülöp T, Nguyen T, Elkouri S, Wilderman I, Bertrand OF, Bostwick JA, Lacasse Y, Pakhale S, Eisenberg MJ. JACC Adv. 2025 Jun;4(6 Pt 2):101833. doi: 10.1016/j.jacadv.2025.101833. PMID: 40579065; PMCID: PMC12277599.
Moiz A, Filion KB, Toutounchi H, Tsoukas MA, Yu OHY, Peters TM, Eisenberg MJ. Ann Intern Med. 2025 Feb;178(2):199-217. doi: 10.7326/ANNALS-24-01590. Epub 2025 Jan 7. PMID: 39761578.
Levett JY, Filion KB, Reynier P, Prell C, Eisenberg MJ. Am J Med. 2023 Aug;136(8):804-813.e4. doi: 10.1016/j.amjmed.2023.04.014.
Moiz A, Eisenberg MJ. Circulation 2023 Jun 20;147(25):1869-1871.
Eisenberg MJ, Hébert-Losier A, Windle SB, Greenspoon T, Brandys T, Fulop T, Nguyen T, Elkouri S, Montigny M, Wilderman I, Bertrand OF, Bostwick JA, Abrahamson J, Lacasse Y, Pakhale S, Cabaussel J, Filion KB. JAMA. 2020 Nov 10;324(18):1844-54. doi: 10.1001/jama.2020.18889.
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