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Iron homeostasis is critical for health and its disruption leads to disease. Thus, iron-deficiency is the most prevalent medical condition affecting one quarter of the world’s population, while iron overload is a hallmark of inherited disorders such as hereditary hemochromatosis or thalassemias. Deregulation of iron metabolism also occurs in common inflammatory, infectious, metabolic, cardiovascular and neurological diseases, as well as in cancer.
The long-term goals of our research program are to:
Kostas Pantopoulos’ ongoing projects in the laboratory focus on the following specific areas:
1. Charlebois, E., Fillebeen, C., Presley, J., Cagnone, G., Lisi, V., Lavallée, V.-P., Joyal, J.-S. and Pantopoulos, K. (2023). Blood, 141, 271-284; editorial in pages 214-216; DOI 10.1182/blood.2022016987; PMID 36351237.
2. Charlebois, E., Fillebeen, C., Katsarou, A., Rabinovich, A., Wisniewski, K., Venkataramani, V., Michalke, B., Velentza, A. and Pantopoulos, K. (2022). eLife, 11, e81332; DOI 10.7554/elife.81332; PMID 36066082.
3. Allameh, A., Hüttmann, N., Charlebois, E., Katsarou, A., Gu, W., Gkouvatsos, K., Pasini, E., Bhat, M., Minic, Z., Berezovski, M., Guido, M., Fillebeen, C. and Pantopoulos, K. (2022). Communications Biology, 5, 153; DOI 10.1038/s42003-022-03108-2; PMID 35194137.
4. Fillebeen, C., Charlebois, E., Wagner, J., Katsarou, A., Mui, J., Vali, H., Garcia dos Santos, D., Ponka, P., Presley, J. and Pantopoulos, K. (2019). Blood, 133, 344-355; DOI 10.1182/blood-2018-05-850404; PMID 30538134.
5. Fillebeen, C., Wilkinson, N., Charlebois, E., Katsarou, A., Wagner, J. and Pantopoulos, K. (2018). Blood, 132, 1829-1841; DOI 10.1182/blood-2018-03-841197; PMID 30213871.
