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Our research focuses on investigating how gene expression is controlled during development and is disrupted in diseases such as cancer. We combine techniques in molecular biology, stem cell biology, functional genomics, and bioinformatics to unravel the complex relationships between chromatin, transcription, and gene expression. We aim to generate novel insights into basic biology, disease mechanisms, and potential therapeutic approaches.
Our research aims to elucidate the mechanisms of gene regulation, with a particular focus on the role of chromatin-modifying factors, including chromatin remodelers and histone acetyltransferases. These enzymes are crucial for regulating coordinated changes in gene expression during normal development, and their dysregulation is implicated in various diseases, such as cancer. We investigate these processes through three interconnected angles:
Wheeler EC, Martin BJE, Doyle WC, Neaher S, Conway CA, Pitton CN, Gorelov RA, Donahue M, Jann JC, Abdel-Wahab O, Taylor J, Seiler M, Buonamici S, Pikman Y, Garcia JS, Belizaire R, Adelman K, Tothova Z.Sci Transl Med. 2024 Jan 3;16(728):eade2774. doi: 10.1126/scitranslmed.ade2774. Epub 2024 Jan 3.
Rogers JM, Mimoso CA, Martin BJ, Martin AP, Aster JC, Adelman K, Blacklow SC. 2024 Jul 12:2024.06.13.598853. doi: 10.1101/2024.06.13.598853.
Martin BJE, Ablondi EF, Goglia C, Mimoso CA, Espinel-Cabrera PR, Adelman K. Cell. 2023 Nov 22;186(24):5290-5307.e26. doi: 10.1016/j.cell.2023.10.006. Epub 2023 Nov 2.
Vlaming H, Mimoso CA, Field AR, Martin BJE, Adelman K. Nat Struct Mol Biol. 2022 Jun;29(6):613-620. doi: 10.1038/s41594-022-00785-9. Epub 2022 Jun 9.
