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Sabrina Wurzba

Sabrina Wurzba, DDS, MSc, PhD

Cancer

Cancer progression, Carcinogenesis, Epigenomic, Genetic, Genomics, Metastasis signaling, Preclinical and animal models, Target and drug discovery
  • Principal Investigator, Lady Davis Institute for Medical Research
  • Associate Professor, Faculty of Medicine, McGill University
  • Research Director, Jewish General Hospital

Contact details

sabrina.wurzba@mcgill.ca

Snapshot

Sabrina Wurzba, DDS, MSc, PhD, is an associate professor at the Department of Otolaryngology – Head and Neck Surgery at McGill University and a principal investigator at the Lady Davis Institute for Medical Research – Segal Cancer Center. She obtained her DDS from the University of Sao Paulo State, Brazil and her MSc and PhD in Pathology and Molecular Biology from the University of Campinas (UNICAMP, Brazil). Following her doctoral studies, Prof. Wurzba completed a postdoctoral training in Genetic/Genomics in Oncology at the Ludwig Cancer Institute under the mentorship of Dr Luiz Paulo Kowalski, a leading expert at AC Camargo Cancer Center. She gained extensive experience in oncology, which she expanded upon trough a complementary postdoctoral training in Experimental Medicine at McGill University, focusing on tumor progression mechanisms and developing orthotopic metastatic models using patient-derived tissues.

Sabrina Wurzba’s research has been published in several peer-reviewed biomedical and medical international journals and she has contributed to book chapters related to the field of oncology science. She has been presented at national and international conferences, including the American Association Head and Neck Society, the Canadian Society of Otolaryngology, the International Academy of Oral Oncology, and International Papillomavirus Society. She also has been serving on several national and international grant panels, editorial boards of biomedical/medical journals, selection and evaluation committees.

Major Research Activities

Currently, Sabrina Wurzba leads innovative basic and translational research aimed to improve prevention, early tumor detection, and discover alternative therapeutic approaches for patients with advanced cancer. Prof. Wurzba’s work centers on the intricate relationship between infections, particularly human papillomavirus (HPV), and the tumor microenvironment. She investigates the key molecular pathways that drive tumor progression and therapeutic resistance, using cutting-edge molecular techniques and diagnostic tools to tackle critical challenges in oncology. Her ultimate aim is to enhance early detection methods, refine staging criteria, and develop personalized, targeted interventions for aggressive cancers, paving the way for improved patient outcomes.

 

The specific research areas in the laboratory include:

  • Translation and Innovation
  • Precision Health
  • Surgical Outcomes and Quality
  • Regenerative Medicine
  • Surgical Oncology
  • Data Science
  • Invasive tumors
  • HPV associated malignancies

Areas of interest comprise:

  • Head and neck cancer genomics and translational applications with a focus on aggressive tumors and HPV-associated malignancies;
  • Innovative concepts of precision/personalized medicine both in the context of therapeutics and preventive strategies;
  • Technologies to identify, understand and develop “smart” drugs against invasive cancer cells and their tissue microenvironment, aiming to improve patients’ outcomes;
  • Drug resistance mechanisms associated with treatment failure and recurrences, seeking to uncover novel approaches to overcome these challenges.

Recent Publications and References

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